TUBERCULOSIS TRANSMISSION

Tuberculosis transmission in Botswana.

Lockman and colleagues recently described a study on conventional and molecular epidemiology of tuberculosis in Botswana (4) and found a rate of clustering cases of pulmonary tuberculosis equal to 42%. The authors were surprised by the result, since they expected a higher rate of clustering in a country such as Botswana, where the incidence of tuberculosis is extremely high (over 500 per 100,00...

Is Early Tuberculosis Death Associated with Increased Tuberculosis Transmission?

INTRODUCTION Tuberculosis (TB) is now a relatively uncommon disease in high income countries. As such, its diagnosis may be missed or delayed resulting in death before or shortly after the introduction of treatment. Whether early TB death is associated with increased TB transmission is unknown. To determine the transmission risk attributable to early TB death we undertook a case-control study. ...

Molecular epidemiology of intra-familial tuberculosis transmission.

Tuberculosis transmission based on molecular epidemiologic research.

Molecular genotyping techniques developed during the past decade and conventional epidemiological methods have been used synergistically in studies of the transmission and pathogenesis of Mycobacterium tuberculosis. Research studies assessing contacts and outbreaks, risk factors for ongoing transmission, and exogenous reinfection with M. tuberculosis have advanced with applied molecular epidemi...

Elephant-to-Human Transmission of Tuberculosis, 2009

In 2009, the Tennessee Department of Health received reports of 5 tuberculin skin test (TST) conversions among employees of an elephant refuge and isolation of Mycobacterium tuberculosis from a resident elephant. To determine the extent of the outbreak and identify risk factors for TST conversion, we conducted a cohort study and onsite assessment. Risk for conversion was increased for elephant ...